Process for the preparation of alkylphosphocholines and the production thereof in pure form

US6028209A · kind A · utility

Assignee

• Asta Medica Aktiengesellschaft · DE

Inventors

• Jurgen Engel · Alzenau, DE
• Bernd Kutscher · Maintal, DE
• Wolfgang Schumacher · Langen, DE
• Ulf Niemeyer · Offenbach, DE
• Alfred Olbrich · Halle (Westf.), DE
• Gerhard Nossner · Feucht, DE

Key dates

• Filing date: Apr 22, 1999
• Grant date: Feb 22, 2000
• Expiry date: Apr 22, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/025
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of C.sub.14 -C.sub.18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C.sub.14 -C.sub.18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or absence of a basic substance in a single vessel process and subsequent reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to form phosphoric acid diester chloride, subsequent hydrolysis and isolation of alkylphosphocholine as well as optionally purification using a mixed-bed ion exchanger or in successive steps with an acid ion exchanger and a basic ion exchanger.