Transgenic animals overexpressing MDM2
US6028245A · kind A · utility
5Cited by
0References
8Claims
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Key dates
| Filing date | Jun 25, 1998 |
| Grant date | Feb 22, 2000 |
| Priority date | — |
| Expiry date | Jun 25, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0331
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to transgenic, non-human animals overexpressing a MDM2 gene. These animals model MDM2 over-expression associated with human tumors, display a major phenotype characterized by the severe skin disorder ichthyosis, and are useful for identifying compounds for the treatment of human disease. Therefore, the invention also relates to methods of using the animals for identifying compounds effective for the treatment of diseases of the skin and respiratory tract, and to the compounds themselves.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.