Ameliorating immunological rejection of allograft

US6030614A · kind A · utility

Assignee

• Plasmaselect GmbH Teterow · DE

Inventors

• Jutta Muller-Derlich · Hersbruck, DE
• Robert Koll · Tauberbischofsheim, DE
• Wolfgang Bohm · Alzenau, DE
• Franz Bieber · Unterschleißheim, DE
• Reiner Spaethe · Starnberg, DE

Key dates

• Filing date: Apr 16, 1996
• Grant date: Feb 29, 2000
• Expiry date: Apr 16, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M1/3679
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides a method to prevent or ameliorate hyperacute or acute rejection of a human donor organ transplanted to a human recipient. Hyperacute rejection would normally occur after a human subject receives a transplanted human organ against which the subject has preformed anti-HLA antibodies. Acute rejection occurs when the recipient of a human organ forms antibodies against that organ after transplant. The invention method comprises passing the plasma of the recipient over a sterile and pyrogen-free column coupled to anti-human immunoglobulin antibodies which bind to and remove a significant portion of the immunoglobulin from the subject's plasma.