Combination method for treating diseases caused by cytokine-mediated toxicity

US6030615A · kind A · utility

Assignee

• The Picower Institute for Medical Research · US

Inventors

• Richard J. Bucala · New York, US
• Robert A. Mitchell · Fort Mill, US
• Jurgen Bernhagen · Tübingen, DE
• Thierry Calandra · New York, US
• Anthony Cerami · Stratford, US

Key dates

• Filing date: Jun 6, 1995
• Grant date: Feb 29, 2000
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is disclosed a method for treating an individual having a disease caused by cytokine-mediated toxicity comprising administering to the individual an effective amount of (a) an antibody that binds to an MIF polypeptide, wherein the MIF polypeptide has a molecular weight of about 12.5 kDa in combination with (b) anti-TNF.alpha., anti-IL1, anti-IFN-.gamma., IL-1RA, a steroid, a glucocorticoid, or IL-10.