Genetically engineered mice and cell lines containing alterations in the genes encoding retinoic acid receptor and retinoid X receptor proteins
US6030794A · kind A · utility
4Cited by
2References
35Claims
0Family size
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Inventors
Key dates
| Filing date | Jun 27, 1995 |
| Grant date | Feb 29, 2000 |
| Priority date | — |
| Expiry date | Jun 27, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/03
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, mice which are heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptor(s), or the normal expression thereof, is desirable.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.