Gastro-specific prodrugs
US6030959A · kind A · utility
19Cited by
5References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 30, 1998 |
| Grant date | Feb 29, 2000 |
| Priority date | — |
| Expiry date | Mar 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound is disclosed having the formula EQU AW--SiR.sup.1 R.sup.2 R.sup.3 wherein R.sup.1 and R.sup.2 are independently alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, alkaryl, or a hydrophilic non-neutral group; R.sup.3 is a hydrophilic non-neutral group; and AW is the covalently bonded form of a drug AWH, wherein W is O, CO.sub.2, NH, S, or an enolate group. This compound serves as a prodrug for the drug AWH. A method for preparing these compounds is also disclosed. Also disclosed is a method of treatment or prevention of gastric ulcers by administering the prodrug compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.