Positive AMPA receptor modulation to enhance brain neurotrophic factor expression

US6030968A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Christine M. Gall · Irvine, US
• Gary Lynch · Irvine, US
• Julie C. Lauterborn · Tecate Mission Road, US
• Peter W. Vanderklish · Laguna Beach, US

Key dates

• Filing date: Sep 17, 1997
• Grant date: Feb 29, 2000
• Expiry date: Sep 17, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/5365
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for increasing the level of neurotrophic factors and neurotrophic factor receptors in the brain of a mammal afflicted with a pathology which produces neurodegeneration without significant loss of memory or learning comprising administering to a mammal an effective amount of an allosteric upmodulator of .alpha.-amino-3-hydroxy-5-methyl-isoxazole-4-proprionic acid (AMPA) receptors.