Acid labile prodrugs
US6030997A · kind A · utility
38Cited by
5References
12Claims
0Family size
Inventors
Key dates
| Filing date | Jan 21, 1998 |
| Grant date | Feb 29, 2000 |
| Priority date | — |
| Expiry date | Jan 21, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and a blocking group, characterized by the presence of a covalent bond which is cleaved at pH values below 7.0. The prodrug may be used in a technique for treating a condition or disease in a mammal related to elevated hydrogen ion concentrations, whereby on administering it to a mammal having such a condition or disease, the pharmacologically active compound is activated selectively within tissues having such elevated hydrogen ion concentrations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.