Preparation of .alpha.-fluoroketones
US6031139A · kind A · utility
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Key dates
| Filing date | Feb 5, 1998 |
| Grant date | Feb 29, 2000 |
| Priority date | — |
| Expiry date | Feb 5, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C45/511
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The use of polar organic solvent as the solvent in the direct fluorination, to make an .alpha.-fluoroketone, of an enol ester or enol trialkylsilyl ether of a compound containing a tautomerisable ketone group, the solvent being relatively inert to fluorine and one in which the enol ester or enol trialkylsilyl ether is relatively stable to hydrolysis. Preferably the solvent is anhydrous, e.g. anhydrous acetonitrile. Alternatively commercial formic acid containing 3% water may be used with a said enol ester.
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