Compositions and methods for modulating leukocyte adhesion to brain endothelial cells
US6033665A · kind A · utility
74Cited by
6References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 1, 1995 |
| Grant date | Mar 7, 2000 |
| Priority date | — |
| Expiry date | Jun 1, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to compositions and methods for modulating the adhesion of leukocytes to brain endothelial cells. More specifically, the present invention relates to the use of reagents to inhibit the binding of VLA-4 leukocyte cell surface receptors to brain endothelial adhesion molecules. Also provided are compositions and methods for treating brain inflammation. A method of inducing brain inflammation as well as an assay for testing anti-inflammatory agents is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.