Double mutant enterotoxin for use as an adjuvant
US6033673A · kind A · utility
38Cited by
2References
19Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 18, 1998 |
| Grant date | Mar 7, 2000 |
| Priority date | — |
| Expiry date | Mar 18, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/832
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed towards a novel composition which is a genetically distinct mutant of E. coli heat-labile enterotoxin (LT). Specifically, the mutant LT designated LT(R192G/L211A) is modified by two amino acid substitutions, i.e., the arginine at amino acid position 192 is replaced by glycine and the leucine at amino acid position 211 is replaced by alanine. The invention relates to compositions and methods for use of the novel double mutant of LT as an adjuvant.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.