Inhibitors of microsomal triglyceride transfer protein and method

US6034098A · kind A · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Scott A. Biller · Hopewell, US
• John K. Dickson · Mount Holly, US
• R. Michael Lawrence · Yardley, US
• David R. Magnin · Hillsborough Township, US
• Michael A. Poss · Lawrenceville, US
• Richard B. Sulsky · Somerville, US
• Joseph A. Tino · Lawrenceville, US
• John E. Lawson · Wallingford, US
• Henry M. Holava · Liverpool, US
• Richard A. Partyka · Liverpool, US

Key dates

• Filing date: Jul 21, 1997
• Grant date: Mar 7, 2000
• Expiry date: Jul 21, 2017

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/044
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.