Heterologous antigens in live cell V. cholerae strains
US6036953A · kind A · utility
4Cited by
3References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 25, 1997 |
| Grant date | Mar 14, 2000 |
| Priority date | — |
| Expiry date | Nov 25, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a V. cholerae cell containing a DNA encoding a fusion polypeptide that includes a heterologous antigenic polypeptide sequence such as a portion of C. difficile toxin A. The fusion polypeptide also includes one of the following: (i) an E. coli hemolysin A subunit (wich is coexpressed with sequences encoding hemolysin B and D subunits); (ii) a secretion signal sequence and cholera toxin A2 subunit (which is coexpressed with cholera toxin B subunit); or (iii) cholera toxin B subunit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.