Methods that detect compounds that disrupt receptor tyrosine kinase/GRB-7 complexes
US6037134A · kind A · utility
7Cited by
2References
10Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 7, 1994 |
| Grant date | Mar 14, 2000 |
| Priority date | — |
| Expiry date | Mar 7, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/20
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to compositions and methods for the prevention, prognostic evaluation, and treatment of oncogenic disorders, especially breast cancer, wherein a protein tyrosine kinase capable of complexing with a member of the SH2- and/or SH3-containing family of adaptor proteins is involved. In a preferred embodiment of the invention, the protein tyrosine kinase is the receptor protein tyrosine kinase HER2, and the adaptor protein is GRB, so that the protein tyrosine kinase/adaptor protein complex is a HER2/GRB-7 complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.