Process for preparing .alpha.-hydroxy acids using microorganism and novel microorganism
US6037155A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 11, 1998 |
| Grant date | Mar 14, 2000 |
| Priority date | — |
| Expiry date | Aug 11, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/83
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for preparing .alpha.-hydroxy acids represented by the general formula (II): RCH(OH)COOH (wherein R represents a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C2-C6 alkenyl group, an optionally substituted C1-C6 alkoxy group, an optionally substituted aryl group, an optionally substituted aryloxy group, or an optionally substituted heterocyclic group) by allowing a microorganism to act on .alpha.-hydroxy nitriles (I): RCH(OH)CN (wherein R is as defined above) to hydrolyze and convert the .alpha.-hydroxy nitrites to .alpha.-hydroxy acids (II), wherein the .alpha.-hydroxy acids (II) are produced and accumulated in an aqueous solvent by a microorganism having the concentration resistance to the .alpha.-hydroxy nitrites (I) and/or .alpha.-hydroxy acids (II) and durability preferably in the presence of a cyanide, and harvested. According to this process, the use of the microorganism having the concentration resistance to the .alpha.-hydroxy nitriles (I) and/or .alpha.-hydroxy acids (II) and durability high enough to permit the activity to persist for a long period of time enables .alpha.-hydroxy acids (II) to be accumulated in high conce…
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