Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor
US6037324A · kind A · utility
21Cited by
8References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 4, 1996 |
| Grant date | Mar 14, 2000 |
| Priority date | — |
| Expiry date | Jan 4, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel compounds comprising peptide sequences which mimic the conserved amino acid motif LDTSL and which have groups bonded to the N- and C-termini. Also provided are methods of inhibiting the interaction of a cell bearing a ligand of MAdCAM-1, such as human .alpha.4.beta.7, with MAdCAM-1 or a portion thereof (e.g., the extracellular domain), comprising contacting the cell with a compound of the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.