Phosphonates, process for preparing the same and medicaments

US6037334A · kind A · utility

Assignee

• Roche Diagnostics GMBH · DE

Inventors

• Ralf Kucznierz · Bad Dürkheim, DE
• Herbert Leinert · Heppenheim, DE
• Wolfgang von der Saal · Rosenheim, DE
• Richard Neidlein · Heidelberg, DE
• Christiane Kehr · Berlin, DE

Key dates

• Filing date: Jul 15, 1999
• Grant date: Mar 14, 2000
• Expiry date: Jul 15, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/59
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## in which R.sub.1, R.sup.2 are the same or different and denote a hydrogen atom, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, an alkenyl group, an alkinyl group or an aralkyl group or R.sup.1 and R.sup.2 together denote an alkylene residue which, together with the bound oxygen atoms and the phosphorus atom carrying the oxygen atoms, forms a saturated 5-membered to 8-membered ring; PA1 R.sup.3 denotes an optionally substituted amino group, an alkyl group, a cycloalkyl residue or an optionally substituted aryl residue; PA1 n denotes an integer between 1 and 4, as well as hydrates, solvates and physiologically tolerated salts thereof, their optically active forms, processes for their production as well as pharmaceutical preparations having factor Xa-inhibitory properties which contain these compounds.