Patent · US Expired

Enzymatic RNA molecules that cleave mutant N-RAS

US6037463A · kind A · utility

21Cited by

1References

23Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Eugen Uhlmann · Königstein, DE
Joachim Engels · Kronberg, DE
Michaela Scherr · Hemmingen, DE
Arnold Ganser · Hannover, DE

Key dates

Filing date	May 23, 1997
Grant date	Mar 14, 2000
Priority date	—
Expiry date	May 23, 2017

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/346
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Enzymatic RNA molecules have been designed that cleave mutant N-ras mRNA, preferably at a NUX cleavage site (N=any base, X=A, C or U). Preferred ribozymes have nucleotide sequences 5'-CCAACACCUGAUGAGCGUUAGCGAAACCUGCU-3' or 5'-UCCCAACCUGAUGAGCGUUAGCGAAACACCUG-3' (SEQ ID NOS:1 and 2), and derivatives thereof. The present invention also provides pharmaceuticals containing such molecules and the use of such molecules for the preparation of pharmaceuticals for the treatment of diseases involving abnormal cell growth and/or differentiation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.