Method of producing L-lysine by fermentation
US6040160A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 29, 1996 |
| Grant date | Mar 21, 2000 |
| Priority date | — |
| Expiry date | May 29, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y104/01016
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A bacterium belonging to the genus Escherichia, which is transformed by introducing, into its cells, a DNA coding for a dihydrodipicolinate synthase originating from a bacterium belonging to the genus Escherichia having mutation to desensitize feedback inhibition by L-lysine and a DNA coding for an aspartokinase III originating from a bacterium belonging to the genus Escherichia having mutation to desensitize feedback inhibition by L-lysine; preferably a bacterium belonging to the genus Escherichia in which a dihydrodipicolinate reductase gene and a diaminopimelate dehydrogenase gene originating from Brevibacterium lactofermentum (or a succinyldiaminopimelate transaminase gene and a succinyldiaminopimelate deacylase gene) are further enhanced, is cultivated in an appropriate medium, L-lysine is produced and accumulated in a culture thereof, and L-lysine is collected from the culture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.