7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them

US6040303A · kind A · utility

Assignee

• Solvay Pharmaceuticals, GmbH · US

Inventors

• Samuel David · Dorval, CA
• Jochen Antel · Annaberg-Buchholz, DE
• Reinhard Brueckner · Hannover, DE
• Dieter Ziegler · Hemmingen, DE
• Christian Eeckhout · Winsen (Aller), DE
• Gerhard-Wilhelm Bielenberg · Alfeld (Leine), DE
• Michael D. Peck · Cincinnati, US

Key dates

• Filing date: Aug 27, 1998
• Grant date: Mar 21, 2000
• Expiry date: Aug 27, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Neurokinin-antagonistic compounds corresponding to formula I: ##STR1## in which R.sup.1 is hydrogen or lower alkyl, PA1 R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and PA1 R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or PA1 R.sup.2 and R.sup.3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, PA1 R.sup.4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and PA1 R.sup.5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or PA1 R.sup.4 and R.sup.5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, PA1 R.sup.6 is lower alkyl, halogen or trifluoromethyl, PA1 R.sup.7 is lower alkyl, halogen or trifluoromethyl, PA1 A is a --(CH.sub.2).sub.n -- group in which n represents an integer from 1 to 3, or an --NH--(CH.sub.2).sub.m -- group in which m represents an integer from 2 to 3, and PA1 B is an alkylene chain with 1 to 3 carbon atoms optionally substituted by lower alkyl, and physiologically acceptable salts thereof and processes for the preparation of these compounds.