Tricycle substituted with azaheterocyclic carboxylic acids

US6040318A · kind A · utility

Assignee

• Novo Nordisk A/S · DK

Inventors

• Knud Erik Andersen
• Tine Krogh J.o slashed.rgensen · Avenue Madeleine, DK
• Rolf Hohlweg
• Erik Fischer · Königstein, DE
• Uffe Bang Olsen
• Zdenek Polivka · Praha, CZ
• Karel Sindelar · Praha, CZ
• Vladimir Valenta · Lučenec, SK

Key dates

• Filing date: Jun 17, 1998
• Grant date: Mar 21, 2000
• Expiry date: Jun 17, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.