Implantation rates after in vitro fertilization, treatment of infertility and early pregnancy loss with a nitric oxide donor alone or in combination with progesterone, and a method for contraception with nitric oxide inhibitors
US6040340A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | May 7, 1996 |
| Grant date | Mar 21, 2000 |
| Priority date | — |
| Expiry date | May 7, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P15/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is provided for the improvement of implantation rates and/or pregnancy rates in a female mammal, comprising administering to a female mammal in whom pregnancy is desired an effective amount of PA1 (a) a nitric oxide synthase substrate, a nitric oxide donor, or both, optionally in combination with PA1 (b) a progestin, and, PA1 (c) optionally, in further combination with an estrogen. A method is also provided for fertility control for a female mammal, comprising administering to a female mammal in whom pregnancy is not desired and at risk for becoming pregnant an effective amount of nitric oxide synthase inhibitor in combination with an antiprogestin. Pharmaceutical compositions are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.