Formoterol process
US6040344A · kind A · utility
49Cited by
1References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 21, 1998 |
| Grant date | Mar 21, 2000 |
| Priority date | — |
| Expiry date | May 21, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is disclosed for the preparation of optically pure isomers of formoterol by the reaction of an optically pure 4-benzyloxy-3-formamidostyrene oxide with an optically pure 4-methoxy-.alpha.-methyl-N-(phenylmethyl)benzeneethanamine followed by debenzylation. Useful intermediates in the process are also disclosed, as are the novel L-tartrate salt of R,R-formoterol and pharmaceutical compositions thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.