Protein and gene for antioxidant response
US6040424A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 19, 1996 |
| Grant date | Mar 21, 2000 |
| Priority date | — |
| Expiry date | Jul 19, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A set of seven nuclear proteins were identified which bind to the antioxidant responsive element (ARE), a DNA sequence present in the promoters of inducible chemoprotective enzymes. One of these ARE binding proteins, here designated ARE-BP-1, has been found to exhibit binding characteristics that parallel the DNA sequences that are necessary for transcriptional induction of the chemoprotective enzymes. ARE-BP-1 is an approximately 160 kDa protein that appears to be a major control switch on the genes which act to protect cells from chemical agents. For binding by ARE-BP-1, a nucleotide sequence must include sequences outside of what was previously through to be the minimally sufficient DNA sequence for inducibility.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.