Patent · US Expired

immunogenic compositions for mucosal administration of pneumococcal surface protein A (PspA)

US6042838A · kind A · utility

19Cited by
3References
8Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMay 19, 1995
Grant dateMar 28, 2000
Priority date—
Expiry dateMay 19, 2015

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2319/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Mucosal administration, particularly intranasally, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with cholera toxin B subunit, provides protection in animals against pneumococcal colonization and systemic infection. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, which can lead to elimination of disease from the population as a whole.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.