Expression vectors encoding recombinant proteins comprising a VPR/VPX virion incorporation domain for targeting into HIV-1 or HIV-2 virions
US6043081A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 7, 1995 |
| Grant date | Mar 28, 2000 |
| Priority date | — |
| Expiry date | Sep 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/6054
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a Vpr protein, a Vpx protein or fragments thereof which permit the development of chimeric molecules that can be specifically targeted into the mature HIV-1 and HIV-2 virions to affect their structural organization and/or functional integrity, thereby resulting in gene therapy for HIV-1 and HIV-2 infections. The present invention also relates to Vpr/Vpx protein fragments, p6 protein, p6 protein fragment, or functional derivatives thereof which interfere with the native Vpr/Vpx incorporation into HIV-1 and HIV-2 virions. The present invention also relates to treatment of HIV-1 and HIV-2 infections based on the proteins of the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.