Amidinoindoles, amidinoazoles, and analogs thereof

US6043257A · kind A · utility

Assignee

• E.I. DU PONT DE NEMOURS AND COMPANY · US

Inventors

• Celia Dominguez · Los Angeles, US
• Qi Han · Wilmington, US
• Daniel E. Duffy · Wilmington, US
• Jeongsook M. Park · Bear, US
• Mimi L. Quan · Newark, US
• Karen A. Rossi · Newtown, US
• Ruth R. Wexler · Chadds Ford, US

Key dates

• Filing date: Oct 21, 1998
• Grant date: Mar 28, 2000
• Expiry date: Oct 21, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula I: ##STR1## wherein W, W.sup.1, W.sup.2, and W.sup.3 are selected from CH and N, provided that one of W.sup.1 and W.sup.2 is C(C(.dbd.NH)NH.sub.2) and at most two of W, W.sup.1, W.sup.2, and W.sup.3 are N and one of J.sup.a and J.sup.b is substituted by --(CH.sub.2).sub.n --Z--A--B, which are useful as inhibitors of factor Xa or thrombin.