Perfluoralkyl substituted metallo-beta-lactamase inhibitors
US6043278A · kind A · utility
3Cited by
2References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 15, 1998 |
| Grant date | Mar 28, 2000 |
| Priority date | — |
| Expiry date | Jun 15, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns perfluoro-lower-alkyl derivatives of amino acids. A new synthetic route is provided for preparing .alpha.-aminotrifluoromethylketones, by converting .alpha.-amino acids to oxazolidin-5-ones which are then reacted with Ruppert's Reagent. Fluorinated derivatives of amino acids and peptides are shown to have a new property of inhibiting or inactivating metallo-.beta.-lactamase enzymes, and are thus valuable components of antibacterial formulations. Certain of the trifluoromethyl derivatives of amino acids are new compounds per se.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.