IgE isoforms and methods of use

US6043345A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Andrew Saxon · Santa Monica, US
• Ke Zhang · Wilmington, US
• Edward E. Max · Bethesda, US
• Jeffrey B. Lyczak · Malden, US
• Sherie L. Morrison · Los Angeles, US

Key dates

• Filing date: Feb 14, 1996
• Grant date: Mar 28, 2000
• Expiry date: Feb 14, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions are provided relating to novel IgE isoforms and their use in immune hypersensitivity diagnosis and treatment. The compositions include transcription and translation products of the immunoglobulin epsilon locus, specific probes for epsilon transcription products, and compounds that specifically bind epitopes of epsilon translation products. Novel products of the epsilon locus include the following transcription products and translation products thereof: CH4-M2", CH4'-CH5-M1'-M2, CH4'-CH5-M2', CH4'-CH5-M2.increment. and CH4-M2'. Such epsilon products, specific probes and binding compounds find use in methods and kits for immune hypersensitivity diagnosis and treatment.