HIV protease inhibitors

US6043357A · kind A · utility

Assignee

• The University Of Queensland · AU

Inventors

• John Abbenante · Brisbane, AU
• Doug Bergman · Brisbane, AU
• Ross Brinkworth · Brisbane, AU
• Robert Dancer · Copenhagen, DK
• Bronwyn Garnham · Canungra, AU
• Peter Hunt · Saffron Walden, GB
• David Fairlie · Faulconbridge, AU
• Darren March · Brisbane, AU
• Jennifer Martin · Brisbane, AU
• Robert C. Reid · Calle de la Era, AU

Key dates

• Filing date: Sep 9, 1997
• Grant date: Mar 28, 2000
• Expiry date: Sep 9, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16122
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A HIV-1 protease inhibitor which includes a n-terminal cycle (A) or a C-terminal cycle (B) or both cycles (A) and (B) wherein Y is selected from side chains of Asn or Ilc or Val or Glu and alkyl of 1-6 carbon atoms inclusive of linear branched chains as well as cycloalkyl; and X is selected from (CH2)n where n=3-6, --CH(OH)--CH(OH)--CH2; CH(CO2H)--CH2--CH2; CH2CONHCHR where R=D or L amino acids and alkyl of 1-6 carbon atoms inclusive of linear or branched chains.