Intermediates in the process for preparing epothilones

US6043372A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Dieter Schinzer · Braunschweig, DE
• Anja Limberg · Penzberg, DE
• Oliver M. Bohm · Magdeburg, DE
• Armin Bauer · Pocking, DE
• Martin Cordes · Sundern, DE

Key dates

• Filing date: Jun 25, 1999
• Grant date: Mar 28, 2000
• Expiry date: Jun 25, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the production of epothilones and intermediate products within the process. Epothilones A and B are natural substances, which can be produced by microorganisms, and the taxols have similar properties and are thus of particular interest in pharmaceutical chemistry.