Water soluble azo dyes and their synthesis and use
US6046312A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 9, 1999 |
| Grant date | Apr 4, 2000 |
| Priority date | — |
| Expiry date | Nov 9, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/144444
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are water soluble azo dyes, represented by Formula I or II, and their synthesis and use. The water soluble azo dyes are synthesized by diazotizing 4-aminopyridine and coupling the resulting diazo intermediate with alkylated metanilic or orthanilic acid. To be suitable for measuring blood glucose levels, the dyes are combined with m-nitrophenyl boronic acid in an aqueous solvent. A combined ao form of the dyes with glucose shows a peak at 540 nm. At this wavelength, the absorptivity has a tendency to increase with the increasing of glucose level, which allows the measurement of blood glucose levels. ##STR1## wherein R has a 1-4 carbon atom length and is an alkyl, a hydroxy alkyl, a carboxyl-containing alkyl, or a sulfonyl-containing alkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.