Cells designed as traps and their use as medicines
US6048525A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Apr 11, 2000 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A cell, particularly a hematopoietic cell population wherein the cells are trapped with respect to activation by an antigen to which the immune system of the host; (human or animal) is to be made tolerant. The cells contain a genetic sequence of which the expression product (e.g. HSV1--TK--) may, when its production is increased so that it is present in a sufficient quantity within said trapped cells, react in situ with a pharmaceutically active substance (e.g. acyclovir) to induce the destruction of the cells and of means (e.g. a promoter of an interleukin receptor controlling the expression of said genetic sequence) which are specifically induced by an activation signal provided by the antigen to the cells, to cause the aforesaid increased production. The production of drugs implementing the above mentioned principles in order to prevent host immune system dysfunctions which are natural (autoimmune diseases) or induced (grafts), is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.