Antibody detection of mismatch repair proteins

US6048701A · kind A · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Kenneth W. Kinzler · Baltimore, US
• Bert Vogelstein · Baltimore, US
• Marilee Burrell · Cambridge, US
• David E. Hill · Gardner, US
• Fredrick S. Leach · Dallas, US

Key dates

• Filing date: Sep 9, 1996
• Grant date: Apr 11, 2000
• Expiry date: Sep 9, 2016

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Antibodies directed to human protein mismatch repair proteins can be used diagnostically to discriminate between proliferating and non-proliferating cells. In addition, they can be used to determine whether cells have a mismatch repair defect caused by a mutation in e.g., hMSH2, hMLH1, or hPMS2. They can also be used to monitor the efficacy of anti-neoplastic therapies.