Recombinant materials for producing humanized anti-IL-8 antibodies
US6048972A · kind A · utility
4Cited by
1References
36Claims
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Key dates
| Filing date | Jun 20, 1997 |
| Grant date | Apr 11, 2000 |
| Priority date | — |
| Expiry date | Jun 20, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Monoclonal antibodies immunospecific for the neutrophil chemotactic factor, IL-8, have been humanized by reshaping the variable regions to conform more closely to human counterparts. These antibodies are useful in immunoassays to detect IL-8 and as ligands on immunoaffinity columns for purification of human IL-8. In addition, the humanized antibodies have an antiinflammatory effect in patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.