Racemization of optically active amines

US6049007A · kind A · utility

Assignee

• BASF SE

Inventors

• Hartmut Riechers · Neustadt, DE
• Joachim Simon · Grevenbroich, DE
• Arthur Hohn · Tauberbischofsheim, DE
• Andreas Kramer · Zürich, CH
• Frank Funke · Bischofswerda, DE
• Wolfgang Siegel · Schifferstadt, DE
• Christoph Nubling · Haßloch, DE

Key dates

• Filing date: Mar 1, 1999
• Grant date: Apr 11, 2000
• Expiry date: Mar 1, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C209/68
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of racemic amines of the formula I ##STR1## where R.sup.1 and R.sup.2 are different and R.sup.1, R.sup.2, R.sup.3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R.sup.3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III ##STR2## and the amine of the formula R.sup.3 NH.sub.2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.