Patent · US Expired

Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling

US6051227A · kind A · utility

135Cited by

3References

23Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

James Allison · New York, US
Dana Leach · Copenhagen, DK
Matthew Krummel · Berkeley, US

Key dates

Filing date	Dec 4, 1996
Grant date	Apr 18, 2000
Priority date	—
Expiry date	Dec 4, 2016

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.