Complex-bound inhibitors of metabolic enzymes capable of being activated, useful as molecular markers for diagnostic and therapy monitoring purposes

US6051390A · kind A · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Gotz Nowak · Erfurt, DE
• Elke Bucha · Erfurt, DE
• Verena Baldinger · Heidelberg, DE

Key dates

• Filing date: May 26, 1998
• Grant date: Apr 18, 2000
• Expiry date: May 26, 2018

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/815
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention relates to the use of an inhibitor of an activatable metabolic enzyme, which inhibitor is bound to a high molecular weight carrier, as a molecular marker for determining the activation of this enzyme for the diagnosis of the enzyme. The invention relates in particular to the use of a thrombin inhibitor, which is bound to a high molecular weight carrier, as a molecular marker for determining clotting activation in clotting diagnosis and therapy monitoring. The invention preferably relates to the use of dextran-hirudin or PEG-coupled hirudin as a molecular marker for clotting diagnosis and therapy monitoring.