Method of producing oxazolidinones, the use thereof and novel oxazolidinones

US6051715A · kind A · utility

Assignee

• Degussa-Huels AG · DE

Inventors

• Karlheinz Drauz · Alzenau, DE
• Gunter Knaup · Bruchköbel, DE
• Stefan Retzow · Alzenau, DE

Key dates

• Filing date: Aug 21, 1997
• Grant date: Apr 18, 2000
• Expiry date: Aug 21, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns a method of producing oxazolidinones of formula (I), wherein R.sup.1 -R.sup.5 have the meanings given in the description, by reacting cyclical anhydrides of formula (II) with carbonyl compounds of general formula (III) at temperatures between ambient temperature and approximately 150.degree. C. The invention also concerns the production of the cyclical anhydrides of formula (II) by reacting N-protected aminodicarboxylic acids of formula (IV) with a dehydrating agent in situ. The invention further concerns the use of oxazolidinones of formula (I) for the .alpha.-selective production of esters of formula (V) and amides of general formula (VII).