Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro
US6054114A · kind A · utility
22Cited by
2References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 7, 1997 |
| Grant date | Apr 25, 2000 |
| Priority date | — |
| Expiry date | May 7, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel organometallic compounds for binding amyloid are described. Methods using such compounds for determining by imaging the localization or quantification of amyloid fibrils in a mammal, for diagnosing the degree of progression of Alzheimer's disease in a mammal, for monitoring the response to a therapy in a mammal having Alzheimer's disease, for identifying an agent useful for treating Alzheimer's disease, for treating Alzheimer's disease, and for detecting the presence of the infectious form of the prion protein, are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.