Methods to identify immunomodulators using cognate interaction of PKC-theta

US6054286A · kind A · utility

Assignee

• Telik, Inc. · US

Inventors

• Hugo O. Villar · Newark, US
• John W. Patterson · Maple Valley, US
• Anna Voronova · San Bruno, US
• Dorit Ron · San Francisco, US
• Lawrence M. Kauvar · San Francisco, US
• Gene Napolitano · New York, US
• Nicki Vasquez · San Francisco, US

Key dates

• Filing date: Jan 15, 1999
• Grant date: Apr 25, 2000
• Expiry date: Jan 15, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/975
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Compounds having immunomodulating activity are identified using a methodology which employs TER14687, TER10311 and/or TER17210 as standards. The effect candidate compounds have on PKC-theta interaction with cognate binding proteins is measured and compared with the standards. The interaction can be measured by a variety of techniques, including assessing translocation of said PKC-theta or fragment. Kits containing the TER14687, TER10311 and/or TER17210 standards are disclosed. TER14687, TER10311 and/or TER17210 are useful in modulating the immune system in a subject by reducing T-cell activity. TER14687, TER10311, TER17210 are used as leads to develop other compounds having immunomodulating activity.