Heterocyclic compounds

US6054458A · kind A · utility

Assignee

• Novo Nordisk A/S · DK

Inventors

• Tine Krogh J.o slashed.rgensen · Avenue Madeleine, DK
• Knud Erik Andersen
• Rolf Hohlweg
• Uffe Bang Olsen
• Erik Fischer · Königstein, DE
• Zdenek Polivka · Praha, CZ
• Kaler Sindelar · Rožmitál pod Třemšínem, CZ

Key dates

• Filing date: Jun 23, 1998
• Grant date: Apr 25, 2000
• Expiry date: Jun 23, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and m are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation, as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.