Medicinal aerosol formulations of formoterol
US6054488A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 2, 1998 |
| Grant date | Apr 25, 2000 |
| Priority date | — |
| Expiry date | Jun 2, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/167
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical suspension formulation suitable for aerosol administration having from 0.0025 to 0.1% w/w of micronized Formoterol, or an acid addition salt thereof, from 0.1 to 5.0% w/w ethanol, HFA 134a, HFA 227 or a mixture of HFA 227 and HFA 134a, and optionally a surfactant other than a monoacetylated or diacetylated monoglyceride, the formulation being further characterized in that it exhibits substantially no growth in particle size or change in crystal morphology of the drug over a prolonged period, is substantially and readily redispersible, and upon redispersion does not flocculate so quickly as to prevent reproducible dosing of the drug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.