Process for preparing 2-chloro-benzimidazole derivatives

US6054589A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Michael Conrad · Wuppertal, DE
• Lutz Assmann · Eutin, DE
• Heinz-Jurgen Wroblowsky · Langenfeld, DE
• Carl Casser · Neunburg vorm Wald, DE
• Dietmar Bielefeldt · Ratingen, DE

Key dates

• Filing date: Jul 17, 1998
• Grant date: Apr 25, 2000
• Expiry date: Jul 17, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A novel process for the preparation of 2-chloro-benzimidazole derivatives of the formula ##STR1## in which A represents optionally halogenated alkylene having 1 or 2 carbon atoms, which process comprises reaction 1,3-dihydro-benzimidazol(ethi)ones of the formula ##STR2## in which X represents oxygen or sulphur, with phosphorus oxychloride. Novel 1,3-dihydro-benzimidazol(ethi)ones of the formula(II) and process for their preparation.