2-mercapto-imidazole derivatives substituted in position 4 (or 5) as antioxidizing agents, method of preparation and applications in the pharmaceutical, cosmetic or food industries
US6056965A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 15, 1997 |
| Grant date | May 2, 2000 |
| Priority date | — |
| Expiry date | Sep 15, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P39/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to 2-mercaptoimidazole derivatives substituted in the 4(or 5)-position. These 2-mercaptoimidazole derivatives are of the general formula (I) below: ##STR1## wherein: R.sub.1, R.sub.2, R.sub.5, R.sub.7 and R.sub.8 are hydrogen, a lower alkyl, an aralkyl or a substituted aralkyl, wherein at least one of R.sub.1 and R.sub.2 is hydrogen; PA0 R.sub.3 is (CH.sub.2).sub.n COR.sub.4, --(CH.sub.2).sub.n N.sup.+ (R.sub.5 R.sub.6 R.sub.7).X.sup.- or --CH.sub.2 CH(COR.sub.4)N.sup.+ (R.sub.5 R.sub.6 R.sub.7).X.sup.- ; PA0 R.sub.4 is OR.sub.8, --NHR.sub.5, --.alpha.-amino acid, PA0 --NHCH.sub.2 CH.sub.2 SO.sub.3.sup.-.Y.sup.+, --NHCH.sub.2 CH.sub.2 CO.sub.2.sup.- Y.sup.+, --OCH.sub.2 CH.sub.2 N.sup.+ (CH.sub.3).sub.3.X.sup.- ; ##STR2## n=1 or 2; X.sup.31 is an anion of an acid acceptable in cosmetics, pharmaceuticals or foodstuffs; and PA0 Y.sup.+ is a cation of a base acceptable in cosmetics, pharmaceuticals or foodstuffs. These compounds are valuable as antioxidants and as active principles of pharmaceutical, cosmetic or food compositions with antioxidant activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.