Preblend of microcrystalline cellulose and lactase for making tablets
US6057139A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 29, 1995 |
| Grant date | May 2, 2000 |
| Priority date | — |
| Expiry date | Jun 29, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/47
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A preblend for making lactase tablets is prepared containing about 1-99% (preferably about 20-60%) by weight lactase and about 1-99% (preferably about 40-80%) by weight microcrystalline cellulose. Lactase used in the preblend may be in combination with up to about 4 parts (preferably about 0.5-2 parts) by weight cutting agent such as sugars, starches, cellulose, and inorganic salts for each part by weight lactase. About 0.5-4% by weight lubricant such as magnesium stearate may be present in the preblend. A preferred preblend contains about 9.6 weight percent lactase and about 90 weight percent microcrystalline cellulose. Another preferred preblend contains about 9.6 weight percent lactase, about 30.0 weight percent microcrystalline cellulose and about 59.4 weight percent mannitol. Each preblend may also contain magnesium stearate. A preferred lactase is from Aspergillus oryzae and the microcrystalline cellulose preferably has an average particle size of about 20-200 .mu.m.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.