Stabilized external guide sequences
US6057153A · kind A · utility
116Cited by
6References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 14, 1997 |
| Grant date | May 2, 2000 |
| Priority date | — |
| Expiry date | Jul 14, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/028
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.