Oxazole derivatives as serotonin-1A receptor agonists
US6057340A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 3, 1999 |
| Grant date | May 2, 2000 |
| Priority date | — |
| Expiry date | Feb 3, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides compounds of Formula 1 having the structure ##STR1## wherein: R.sub.1 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, benzyloxy, trifluoromethyl, chloro, bromo, or fluoro; PA0 a dashed line indicates an optional bond, PA0 X is NR.sub.4, or no atom; PA0 R.sub.2 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, cycloalkylalkyl wherein the cycloalkyl moiety is 3-8 carbon atoms and the alkyl moiety is 1-6 carbon atoms, aryl of 5-12 carbon atoms, or arylalkyl of 6-12 carbon atoms; PA0 R.sub.3 is aryl of 5-12 carbon atoms, arylalkyl of 6-12 carbon atoms, or heteroaryl of 5-12 atoms; PA0 R.sub.4 is hydrogen or alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of psychosis (e.g. schizophrenia), anxiety, depression and related CNS disorders and other conditions such as the treatment of alcohol and drug withdrawal, sexual dysfunction and memory deficits associated with Alzheimer's disease and other dementias.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.