Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US6057347A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 16, 1997 |
| Grant date | May 2, 2000 |
| Priority date | — |
| Expiry date | Sep 16, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.