Curacin A analogs exhibiting antiproliferative activity against cells
US6057348A · kind A · utility
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10Claims
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Key dates
| Filing date | Jul 14, 1998 |
| Grant date | May 2, 2000 |
| Priority date | — |
| Expiry date | Jul 14, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Isomers of a cytotoxic compound isolated and purified from a marine cyanobacterium Lyngbya majuscula are disclosed. The compound, termed "curacin D", exhibits substantial biological activity against proliferating cells. Analogs of curacin A also are described, as are formulations that include curacin D and the curacin A analogs. The curacins A-D and analogs of curacin A exhibit antimitotic behavior.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.